What SpO2 targets are commonly used for preterm infants receiving oxygen therapy?

• A. Typically 90-95% SpO2 to balance oxygenation and retinopathy risk.
• B. Always above 98%.
• C. Below 85%.
• D. Only room air without supplemental oxygen.

Answer: (C)

Oxygen targets for preterm infants on supplemental oxygen focus on balancing adequate tissue oxygenation with minimizing oxygen-related eye damage. The commonly used goal is about 90-95% SpO2. This range provides sufficient oxygen delivery while reducing the risk of retinopathy of prematurity that comes with higher saturations. Saturations pushed well above this range don’t improve outcomes and can increase ROP risk, while saturations consistently below about 85% raise the danger of hypoxemia and organ injury. Some units may use a slightly broader target (for example, 85-92% or 88-95%), but aiming roughly for 90-95% is a standard practice.